Dimethylformamide → N-(4'-Chlorobiphenyl-4-carbonyl)-2(R)-phenyl-aziridine

HRID 54518

反応式

HRID 54518 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:17]1(N2CC2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH3:26][N:27]([CH:29]=O)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([N:27]3[CH2:29][C@H:26]3[C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[O:16])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 6228Dimethylformamide2 回HCID 696731-PhenylaziridineHCID 6160024-Biphenylcarboxylic acid, 4'-chloro-

生成物 1

HCID 22872208N-(4'-Chlorobiphenyl-4-carbonyl)-2(R)-phenyl-aziridine

実験手順

To a solution of 0.232 g of 4'-chlorobiphenyl-4-carboxylic acid in 3 ml of dry DMF, 0.18 g of N,N'-carbonyl-diimidazole are added with stirring at room temperature under argon atmosphere. After one hour a solution of 0.12 g of phenyl-aziridine in 0.5 ml of dry DMF is added dropwise. The reaction mixture is stirred for 21 hours and thereafter worked up as described in example 1. The compound is obtained as a pale yellow oil and used without purification in the next step.

後処理

  1. stirringThe reaction mixture is stirred for 21 hours
  2. customThe compound is obtained as a pale yellow oil
  3. customused without purification in the next step

出典と根拠

ORDレコード
ord-50be94b7d1fa41d4856b0969252a7d2c
出典データセット
uspto-grants-1997_04
特許番号
US05622982

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