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2-Nitrophenol → Benzyl 2-nitrophenyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Nitrophenol | HCID 6947 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Benzyl 2-nitrophenyl ether | HCID 736266 | — |
反応手順
A stirred mixture of 2-nitrophenol (13.9 g, 0.10 mol), benzyl bromide (12.0 ml, 0.10 mol) and anhydrous potassium carbonate (30 g, 0.22 mol) in acetone (200 ml) is heated under reflux for 16 hours, cooled, poured onto ice-dilute hydrochloric acid, and extracted with dichloromethane. The extract is dried and evaporated and the residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05622969 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-e44dbfde469446e78ff3839f598915a5 |
| 出典メモ | uspto-grants-1997_04 |