Indole → 7-(Benzyloxy)-1H-indole

HRID 54522

反応式

HRID 54522 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C([O:13][CH2:14][CH3:15])(=O)C>[Ni].C(O)C>[CH2:14]([O:13][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[NH:1][CH:2]=[CH:3]2)[C:15]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 798IndoleHCID 8857Ethyl Acetate

生成物 1

HCID 2607987-(Benzyloxy)-1H-indole

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

Wet Raney nickel is added in portions to a stirred refluxing solution of 7-(benzyloxy)-3-methylthio)indole (4.0 g, 14.9 mmol) in ethyl acetate (100 ml) and ethanol (60 ml) until all the starting material has been consumed (by RP HPLC). The mixture is filtered, the filtrate evaporated and the residue chromatographed on silica in ethyl acetate-hexane (1:8) to give a pale oil.

後処理

  1. customhas been consumed (by RP HPLC)
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated
  4. customthe residue chromatographed on silica in ethyl acetate-hexane (1:8)
  5. customto give a pale oil

出典と根拠

ORDレコード
ord-1390f576f6564c378bf76d8f0a770020
出典データセット
uspto-grants-1997_04
特許番号
US05622969

関連ノート

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