化工社化工社 化学情報印刷レポート · 研究参考用
1,2-Epoxy-3-fluoropropane → 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Epoxy-3-fluoropropane | HCID 10418 | — |
| 反応物 | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol | HCID 67171089 | 43.9% |
反応手順
Ethanol (15 mL) solution of 272 mg of epifluorohydrin and 500 mg of 1-(4-nitrophenyl)piperazine was heated under reflux for 15 hours, and then the reaction liquid was concentrated under reduced pressure. The residue was solidified from ethyl acetate to obtain 300 mg of the entitled compound as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07935708B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-d7023ffab59d484ebf7ad48ae95afa9f |
| 出典メモ | uspto-grants-2011_05 |