1,2-Epoxy-3-fluoropropane → 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol

HRID 545238

反応式

HRID 545238 の反応式
[CH2:1]([CH:3]1[O:5][CH2:4]1)[F:2].[N+:6]([C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:11][CH:10]=1)([O-:8])=[O:7]>C(O)C>[F:2][CH2:1][CH:3]([OH:5])[CH2:4][N:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([N+:6]([O-:8])=[O:7])=[CH:14][CH:13]=2)[CH2:16][CH2:17]1

参加物

4

反応物 2

HCID 104181,2-Epoxy-3-fluoropropaneHCID 804471-(4-Nitrophenyl)piperazine

生成物 1

HCID 671710891-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol収率 43.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethanol (15 mL) solution of 272 mg of epifluorohydrin and 500 mg of 1-(4-nitrophenyl)piperazine was heated under reflux for 15 hours, and then the reaction liquid was concentrated under reduced pressure. The residue was solidified from ethyl acetate to obtain 300 mg of the entitled compound as a yellow solid.

後処理

  1. temperatureunder reflux for 15 hours
  2. customthe reaction liquid
  3. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-d7023ffab59d484ebf7ad48ae95afa9f
出典データセット
uspto-grants-2011_05
特許番号
US07935708B2

関連ノート

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