Hydrochloric Acid → 2-(3-Bromophenyl)propan-2-ol

HRID 545241ノート

反応式

HRID 545241 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[CH3:11][Mg]I.C(OCC)C.C(OCC)C.Cl>O>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([OH:10])([CH3:11])[CH3:9])[CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 165023'-BromoacetophenoneHCID 178467823HCID 178467823、化合物

生成物 1

HCID 150723832-(3-Bromophenyl)propan-2-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a nitrogen atmosphere with cooling with ice, 5.29 mL of 3′-bromoacetophenone was added to 25 mL of 2 M methylmagnesium iodide/diethyl ether solution and 100 mL of diethyl ether, and stirred for 20 minutes. Water and 2 N hydrochloric acid were added to the reaction liquid, extracted with ethyl acetate, washed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain crude 2-(3-bromophenyl)propan-2-ol.

後処理

  1. extractionextracted with ethyl acetate
  2. washwashed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customThe solvent was evaporated away under reduced pressure

出典と根拠

ORDレコード
ord-1996b98aa229444eb0b4ab31417701f3
出典データセット
uspto-grants-2011_05
特許番号
US07935708B2

反応ノート

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