Bromobenzene → HCID 57619584、化合物

HRID 545281

反応式

HRID 545281 の反応式
[CH3:1][N:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([C:10]([O:12]CC)=O)[C:3]1=[O:15].[NH2:16][C:17]1[N:21]=[C:20]([CH3:22])[NH:19][N:18]=1.BrC1C=CC=CC=1>>[CH3:1][N:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([C:10]([NH:16][C:17]2[N:21]=[C:20]([CH3:22])[NH:19][N:18]=2)=[O:12])[C:3]1=[O:15]

参加物

4

反応物 3

HCID 7961BromobenzeneHCID 2346103-Amino-5-methyl-4H-1,2,4-triazoleHCID 57619607Ethyl 1,6-dimethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylate

生成物 1

HCID 57619584HCID 57619584、化合物収率 88.6%

実験手順

211 mg of ethyl 1,6-dimethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxyl ate and 90 mg of 3-amino-5-methyl-1,2,4-triazole were added to 2.5 ml of bromobenzene, then, the mixture was stirred for 7 hours under heat refluxing condition. The reaction mixture was cooled to room temperature. The resulting solid was collected by filtration, and washed with a mixed solvent of t-butyl methyl ether and hexane and dried to obtain 214 mg of 1,6-dimethyl-4-hydroxy-N-(5-methyl-1,2,4-triazol-3-yl)-2-ox o-1,2-dihydropyridine-3-carboxamide (hereinafter, referred to as present compound 24) represented by the formula:

後処理

  1. temperatureunder heat
  2. temperaturerefluxing condition
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with a mixed solvent of t-butyl methyl ether and hexane
  5. customdried

出典と根拠

ORDレコード
ord-a3570fb61a8c4e51925fb9db7204cd03
出典データセット
uspto-grants-2011_05
特許番号
US07935716B2

関連ノート

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