1,4'-Bipiperidin-4-ol → (4-Hydroxy-[1,4']bipiperidinyl-1'-yl)-[5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-methanone

HRID 545415

反応式

HRID 545415 の反応式
[I:1][C:2]1[N:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)[N:4]([CH3:17])[C:3]=1[C:18]([OH:20])=O.[N:21]1([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH2:26][CH2:25][CH:24]([OH:27])[CH2:23][CH2:22]1>>[OH:27][CH:24]1[CH2:23][CH2:22][N:21]([CH:28]2[CH2:33][CH2:32][N:31]([C:18]([C:3]3[N:4]([CH3:17])[C:5]([C:7]4[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:8]=4)=[N:6][C:2]=3[I:1])=[O:20])[CH2:30][CH2:29]2)[CH2:26][CH2:25]1

参加物

3

反応物 2

HCID 220613421,4'-Bipiperidin-4-olHCID 671332315-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carboxylic acid

生成物 1

HCID 57541095(4-Hydroxy-[1,4']bipiperidinyl-1'-yl)-[5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-methanone

実験手順

In analogy to the procedure described for example 2, 5-iodo-3-methyl-2-(3-trifluoromethyl-phenyl)-3H-imidazole-4-carboxylic acid (example 36) was coupled with [1,4′]bipiperidinyl-4-ol to give the title compound as light red solid. MS: 563.2 (MH+).

出典と根拠

ORDレコード
ord-f659f54d5b384fa598484b831946b276
出典データセット
uspto-grants-2011_05
特許番号
US07935707B2

関連ノート

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