3-Chloro-4-hydrazinobenzonitrile → HCID 57431653、化合物

反応式

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][C:3]=1[NH:10]N.O=[C:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22])[CH2:15][CH2:14]1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[C:4]2[C:3]=1[NH:10][C:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20](=[O:24])[CH:21]([CH3:22])[CH3:23])[CH2:15][C:14]2=1

参加物

反応物 2

HCID 27969643-Chloro-4-hydrazinobenzonitrile

HCID 215339942-Methyl-N-(4-oxocyclohexyl)propanamide

生成物 1

HCID 57431653HCID 57431653、化合物収率 50%

実験手順

Prepare the title compound by essentially following the procedure as described in Preparation 4 (Method 2) with 2-chloro-4-cyanophenylhydrazine (Preparation 13) and N-(4-oxo-cyclohexyl)-isobutyramide, to obtain the title compound as a pink powder in 50% yield. MS (ES): m/z 316 (M+H), 314 (M−H); HPLC (Method A): Rt=1.96, (90%).

出典と根拠

ORDレコード: ord-34ea8244276e4e96a2aa3b4939bac136
出典データセット: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07935722B2

反応ノート

読み込み中…

参加物