3-Fluorobenzyl bromide → HCID 59161232、化合物

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([C:21]#[N:22])[CH:5]=[C:6]2[C:14]=1[NH:13][C:12]1[CH2:11][CH2:10][CH:9]([NH:15][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])[CH2:8][C:7]2=1.[F:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH2:27]Br>>[Cl:1][C:2]1[CH:3]=[C:4]([C:21]#[N:22])[CH:5]=[C:6]2[C:14]=1[N:13]([CH2:27][C:26]1[CH:29]=[CH:30][CH:31]=[C:24]([F:23])[CH:25]=1)[C:12]1[CH2:11][CH2:10][CH:9]([NH:15][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])[CH2:8][C:7]2=1

参加物

反応物 2

HCID 680073-Fluorobenzyl bromide

HCID 57431653HCID 57431653、化合物

生成物 1

HCID 59161232HCID 59161232、化合物収率 10%

実験手順

Prepare the title compound by essentially following the procedure as described in Example 96 with N-(8-chloro-6-cyano-2,3,4,9-tetrahydro-1H-carbazol-3-yl)-isobutyramide (Preparation 18) and 3-fluorobenzyl bromide, to obtain the title compound as a white solid in 10% yield. MS (ES): 424 (M+1), 422 (M−1); HPLC (Method A): Rt=3.18 (92%).

出典と根拠

ORDレコード: ord-f711da0c3ab641cbac7512a5e9c9ad73
出典データセット: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07935722B2

反応ノート

読み込み中…

参加物