(6-Bromo-3-fluoropyridin-2-yl)methanol → (3-Fluoropyridin-2-yl)methanol
反応式
Br[C:2]1[N:7]=[C:6]([CH2:8][OH:9])[C:5]([F:10])=[CH:4][CH:3]=1>CO>[F:10][C:5]1[C:6]([CH2:8][OH:9])=[N:7][CH:2]=[CH:3][CH:4]=1参加物
3
実験手順
Dissolve (6-bromo-3-fluoro-pyridin-2-yl)-methanol (850 mg, 4.13 mmol) in methanol (40 mL) then purge the solution with nitrogen. Add palladium on carbon (200 mg of 5% wet) and stir the mixture under a hydrogen atmosphere (2 balloons) for 20 h. Filter the mixture through Celite® and wash the filter cake with methanol.
後処理
- customthen purge the solution with nitrogen
- filtrationFilter the mixture through Celite®
- washwash the filter cake with methanol
出典と根拠
- ORDレコード
- ord-a9b186df686f47e8baf5cb6124ab1aa7
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07935722B2
反応ノート
読み込み中…