関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromo-4'-methylacetophenone | HCID 69272 | — |
| 反応物 | N-(4-acetyl-3-hydroxyphenyl)acetamide | HCID 2775185 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-[3-methyl-2-(4-methylbenzoyl)-1-benzofuran-6-yl]acetamide | HCID 19959494 | — |
反応手順
0.72 g (3.75 mmol) of N-(4-acetyl-3-hydroxy-phenyl)acetamide and 0.81 g (4.1 mmol) of 2-bromo-4-methylacetophenone were dissolved in 5 ml DMF and 1,55 g (11.25 mmol) of potassium carbonate were added. The suspension was heated to 60° C. for 1 h and ethylacetate was added. The organic phase was washed three times with water, one time with a NaCl solution, dried over Na2SO4 and concentrated in vacuo. The residue was further purified by crystallisation (ethanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05622989 |
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| 出典データセット | uspto-grants-1997_04 |
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| ORD ID | ord-0a69d66834ca489699003732fef2a0dc |
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| 出典メモ | uspto-grants-1997_04 |
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