Ethyl Acetate → N-[3-methyl-2-(4-methylbenzoyl)-1-benzofuran-6-yl]acetamide

HRID 54589

反応式

HRID 54589 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[OH:14])(=O)[CH3:2].[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH2:24]Br)=[O:23])=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+].C(OC(=O)C)C>CN(C=O)C>[CH3:2][C:1]1[C:4]2[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=2[O:14][C:24]=1[C:22](=[O:23])[C:19]1[CH:20]=[CH:21][C:16]([CH3:15])=[CH:17][CH:18]=1

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 692722-Bromo-4'-methylacetophenoneHCID 2775185N-(4-acetyl-3-hydroxyphenyl)acetamide

生成物 1

HCID 19959494N-[3-methyl-2-(4-methylbenzoyl)-1-benzofuran-6-yl]acetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

0.72 g (3.75 mmol) of N-(4-acetyl-3-hydroxy-phenyl)acetamide and 0.81 g (4.1 mmol) of 2-bromo-4-methylacetophenone were dissolved in 5 ml DMF and 1,55 g (11.25 mmol) of potassium carbonate were added. The suspension was heated to 60° C. for 1 h and ethylacetate was added. The organic phase was washed three times with water, one time with a NaCl solution, dried over Na2SO4 and concentrated in vacuo. The residue was further purified by crystallisation (ethanol).

後処理

  1. washThe organic phase was washed three times with water, one time with a NaCl solution
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated in vacuo
  4. customThe residue was further purified by crystallisation (ethanol)

出典と根拠

ORDレコード
ord-0a69d66834ca489699003732fef2a0dc
出典データセット
uspto-grants-1997_04
特許番号
US05622989

関連ノート

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