ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Dicyclohexylcarbodiimide → N-[N'-(Fluorenylmethyloxycarbonyl)glycyl]-N-[2-(thymin-1-yl)ethyl]-glycine tert-butyl ester

HRID 54618
ノート
印刷プレビュー

反応式

HRID 54618 の反応式
[C:1]([O:5][C:6](=[O:20])[CH2:7][NH:8][CH2:9][CH2:10][N:11]1[CH:19]=[C:17]([CH3:18])[C:15](=[O:16])[NH:14][C:12]1=[O:13])([CH3:4])([CH3:3])[CH3:2].[C:21]1([CH2:34][O:35][C:36]([NH:38][CH2:39][C:40](O)=[O:41])=[O:37])[C:33]2[CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]=2[CH:24]=[CH:23][CH:22]=1.C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C=O>[C:1]([O:5][C:6](=[O:20])[CH2:7][N:8]([C:40](=[O:41])[CH2:39][NH:38][C:36]([O:35][CH2:34][C:21]1[C:33]2[CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]=2[CH:24]=[CH:23][CH:22]=1)=[O:37])[CH2:9][CH2:10][N:11]1[CH:19]=[C:17]([CH3:18])[C:15](=[O:16])[NH:14][C:12]1=[O:13])([CH3:4])([CH3:2])[CH3:3]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 14767770Fluorenylmethoxy-carbonyl-glycineHCID 19959625N-[2-(Thymin-1-yl)ethyl]-glycine tert-butyl ester

生成物 1

HCID 86750730N-[N'-(Fluorenylmethyloxycarbonyl)glycyl]-N-[2-(thymin-1-yl)ethyl]-glycine tert-butyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The product from Example 8 (3.78 g; 13 mmol) and N-(fluorenylmethyloxycarbonyl)glycine (5.9 g; 20 mmol) are dissolved in anhydrous N,N-dimethylformamide (160 ml) under a protective atmosphere of argon gas. N,N'-Dicyclohexylcarbodiimide (4.11 g; 20 mmol) is added in portions at 0° C. The mixture is stirred at room temperature for 21 h and the solid which has precipitated is subsequently filtered off with suction. The solution is then concentrated in vacuo, and subsequently distilled repeatedly with toluene, and the crude product is chromatographed on silica gel. (Eluent: toluene/ethanol, 30:1-20:1). Yield: 6.33 g (82%).

後処理

  1. customthe solid which has precipitated
  2. filtrationis subsequently filtered off with suction
  3. concentrationThe solution is then concentrated in vacuo
  4. distillationsubsequently distilled repeatedly with toluene
  5. customthe crude product is chromatographed on silica gel

出典と根拠

ORDレコード
ord-e8b00b43fa464d3d9c3332972aa04cb6
出典データセット
uspto-grants-1997_04
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05623049

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート