Sulfuric Acid → 3-Maleimidophenyl boronic acid

HRID 54631

反応式

HRID 54631 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([B:8]([OH:10])[OH:9])[CH:5]=[CH:6][CH:7]=1.COC(N1[C:19](=[O:20])[CH:18]=[CH:17][C:16]1=[O:21])=O.OS(O)(=O)=O>C([O-])(O)=O.[Na+].O>[C:16]1(=[O:21])[N:1]([C:2]2[CH:3]=[C:4]([B:8]([OH:10])[OH:9])[CH:5]=[CH:6][CH:7]=2)[C:19](=[O:20])[CH:18]=[CH:17]1

参加物

6

反応物 3

HCID 1118Sulfuric AcidHCID 922693-Aminophenylboronic acidHCID 580610N-(Methoxycarbonyl)maleimide

生成物 1

HCID 224930233-Maleimidophenyl boronic acid収率 64.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 516892Sodium Bicarbonate溶媒

反応条件

温度
0 °C

実験手順

(3-Aminophenyl)boronic acid (1.26 grams, 0.01 mole) is dissolved in saturated NaHCO3 (50 ml) by briefly heating the mixture on a hot plate. The solution is cooled in an ice bath to approximately 0° C., and N-methoxycarbonylmaleimide (1.55 grams, 0.01 mole) added with vigorous stirring. After 10 min. the solution is diluted with water (200 ml) and then stirred at room temperature for 30 to 40 min. The pH is adjusted to approximately 5.5 by addition of 1M H2SO4, and the precipitate collected by filtration. The precipitate is washed with 1M H2SO4 (2×50 ml), and then dried overnight in vacuo over NaOH pellets to afford 1.39 grams (64% yield) of (3-maleimidophenyl)boronic acid. The structure was confirmed by 300 MHz, 1H NMR spectrometry in d6 -DMSO.

後処理

  1. temperatureby briefly heating the mixture on a hot plate
  2. filtrationthe precipitate collected by filtration
  3. washThe precipitate is washed with 1M H2SO4 (2×50 ml)
  4. dry with materialdried overnight in vacuo over NaOH pellets

出典と根拠

ORDレコード
ord-8ed6c8aa8b684581b325a3620b1803c8
出典データセット
uspto-grants-1997_04
特許番号
US05623055

関連ノート

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