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6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline → 3,4-Dihydro-6,7-dimethoxy-1-methylisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline | HCID 10302 | — |
| 反応物 | Acetic anhydride pyridine | HCID 22348678 | — |
| 生成物 | 3,4-Dihydro-6,7-dimethoxy-1-methylisoquinoline | HCID 22652 | — |
反応手順
6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, conversion>99%, ee 82% (GC, sample derivatised by treatment with acetic anhydride pyridine, Chirasil DEX CB, 25 m×0.25 mm, injector/detector 200° C., helium 20 psi, 170° C. for 20 minutes then ramp at 5° C./min to 200° C., hold for 10 minutes, retention times 30.18 minutes and 30.45 minutes).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07935841B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-c4b619383e4c49889daed010d1c31a9b |
| 出典メモ | uspto-grants-2011_05 |