Methyl 3-chloro-4-fluoro-alpha-azidocinnamate → Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

HRID 546405ノート

反応式

HRID 546405 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[CH:5]=[C:6]([N:11]=[N+]=[N-])[C:7]([O:9][CH3:10])=[O:8]>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][C:16]=1[F:17])[NH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5]2

参加物

3

反応物 1

HCID 54554773Methyl 3-chloro-4-fluoro-alpha-azidocinnamate

生成物 1

HCID 18986230Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A mixture of methyl 3-chloro-4-fluoro-α-azidocinnamate (Japanese Patent Application Laid-Open No. 149723/1995) (1.85 g) and xylene (140 ml) was heated under reflux for 1 hour, and the solvent was then distilled off. The residue was purified by column chromatography on silica gel (dichloromethane) to obtain the title compound (491 mg) as colorless powder.

後処理

  1. temperatureunder reflux for 1 hour
  2. distillationthe solvent was then distilled off
  3. customThe residue was purified by column chromatography on silica gel (dichloromethane)

出典と根拠

ORDレコード
ord-a3e5e9f52c684f409454aa374302f0c5
出典データセット
uspto-grants-2011_05
特許番号
US07935824B2

反応ノート

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