Methyl 7-chloroisoquinoline-3-carboxylate → 7-Chloroisoquinoline-3-carboxylic Acid Hydrochloride
反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([O:14]C)=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1>Cl>[ClH:1].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([OH:14])=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1参加物
3
実験手順
Methyl 7-chloroisoquinoline-3-carboxylate (0.23 g) was dissolved in concentrated hydrochloric acid (10 ml) to heat the mixture for 18 hours under reflux. The temperature of the reaction mixture was dropped to room temperature, and deposits were collected by filtration and then washed with water to obtain the title compound (0.21 g) as a colorless solic.
後処理
- temperatureto heat the mixture for 18 hours
- temperatureunder reflux
- additionThe temperature of the reaction mixture was dropped to room temperature
- filtrationdeposits were collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-75f505b5fc6641e0b7f49079a3f232d4
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07935824B2
反応ノート
読み込み中…