Hydrochloric Acid → HCID 67056679、化合物

HRID 546515ノート

反応式

HRID 546515 の反応式
C(OC([NH:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][C:14]2[N:17]=[C:18]([C:20]([NH:22][C@@H:23]3[CH2:28][CH2:27][CH2:26][CH2:25][C@@H:24]3[NH:29][C:30]([C:32]3[NH:33][C:34]4[C:39]([CH:40]=3)=[CH:38][C:37]([Cl:41])=[CH:36][CH:35]=4)=[O:31])=[O:21])[S:19][C:13]=2[CH2:12]1)=O)(C)(C)C.C(O)C.Cl>ClCCl>[ClH:41].[NH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][C:14]2[N:17]=[C:18]([C:20]([NH:22][C@@H:23]3[CH2:28][CH2:27][CH2:26][CH2:25][C@@H:24]3[NH:29][C:30]([C:32]3[NH:33][C:34]4[C:39]([CH:40]=3)=[CH:38][C:37]([Cl:41])=[CH:36][CH:35]=4)=[O:31])=[O:21])[S:19][C:13]=2[CH2:12]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 58822122(+/-)-cis-N1-[[5-[2-(tert-Butoxycarbonylamino)-ethyl]-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl]carbonyl]-N 2-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine

生成物 1

HCID 67056679HCID 67056679、化合物収率 182.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(±)-cis-N1-[[5-[2-(tert-Butoxycarbonylamino)-ethyl]-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl]carbonyl]-N2-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine (450 mg) was dissolved in dichloromethane (5 ml), and a saturated ethanol solution (30 ml) of hydrochloric acid was added to stir the mixture at room temperature for 1 minute. The reaction mixture was concentrated under reduced pressure, ethyl acetate was added to the residue, and solids deposited were collected by filtration to obtain the title compound (367 mg) as a pale yellow amorphous solid.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure, ethyl acetate
  2. additionwas added to the residue, and solids
  3. filtrationdeposited were collected by filtration

出典と根拠

ORDレコード
ord-c4cc78300f71488c9d66a0ff6bfd8580
出典データセット
uspto-grants-2011_05
特許番号
US07935824B2

反応ノート

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