ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Hydrochloric Acid → 2-(4-{4,4-Dimethyl-2,5-dioxo-3-[2-(pyridin-3-ylamino)pyridin-4-ylmethyl]imidazolidin-1-yl}-phenyl)-2-methylpropionic acid

HRID 546631
ノート
印刷プレビュー

反応式

HRID 546631 の反応式
[CH3:1][C:2]1([CH3:36])[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([CH3:20])([CH3:19])[C:15]([O:17]C)=[O:16])=[CH:10][CH:9]=2)[C:4](=[O:21])[N:3]1[CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[C:25]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=2)[CH:24]=1.[OH-].[K+].Cl>CO.O>[CH3:1][C:2]1([CH3:36])[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([CH3:19])([CH3:20])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)[C:4](=[O:21])[N:3]1[CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[C:25]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=2)[CH:24]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 57626005HCID 57626005、化合物

生成物 1

HCID 576259742-(4-{4,4-Dimethyl-2,5-dioxo-3-[2-(pyridin-3-ylamino)pyridin-4-ylmethyl]imidazolidin-1-yl}-phenyl)-2-methylpropionic acid収率 68.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒
HCID 962
Water
溶媒

実験手順

To a solution of 0.34 g of methyl 2-[4-(4,4-dimethyl-2,5-dioxo-3-{[2-(pyridin-3-ylamino)pyridin-4-yl]methyl}imidazolidin-1-yl)phenyl]-2-methylpropanoate obtained in stage e) below in 20 mL of methanol, at room temperature, are added 7 mL of 1N potassium hydroxide. The reaction medium is heated at reflux for two hours and concentrated under reduced pressure. The residue obtained is taken up in 10 mL of water and then acidified with 2N HCl to pH=5. The white solid formed is filtered off and then dried to give 0.225 g of 2-[4-(4,4-dimethyl-2,5-dioxo-3-{[2-(pyridin-3-ylamino)pyridin-4-yl]methyl}imidazolidin-1-yl)phenyl]-2-methylpropanoic acid, the characteristics of which are as follows:

後処理

  1. temperatureThe reaction medium is heated
  2. temperatureat reflux for two hours
  3. concentrationconcentrated under reduced pressure
  4. customThe residue obtained
  5. customThe white solid formed
  6. filtrationis filtered off
  7. customdried

出典と根拠

ORDレコード
ord-60e06ad5799544b4931e40ef9dc47edd
出典データセット
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07935819B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート