Ethyl Acetate → HCID 86628503、化合物

HRID 546664ノート

反応式

HRID 546664 の反応式
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[F:23][C:24]1[CH:25]=[C:26]([C:30]2([CH2:55][OH:56])[CH2:35][CH2:34][CH2:33][N:32]3[N:36]=[C:37](/[CH:39]=[CH:40]/[C:41]4[CH:46]=[CH:45][C:44]([N:47]5[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]5)=[C:43]([O:53][CH3:54])[CH:42]=4)[N:38]=[C:31]23)[CH:27]=[CH:28][CH:29]=1.C(OCC)(=O)C.O.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[F:23][C:24]1[CH:25]=[C:26]([C:30]2([CH:55]=[O:56])[CH2:35][CH2:34][CH2:33][N:32]3[N:36]=[C:37](/[CH:39]=[CH:40]/[C:41]4[CH:46]=[CH:45][C:44]([N:47]5[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]5)=[C:43]([O:53][CH3:54])[CH:42]=4)[N:38]=[C:31]23)[CH:27]=[CH:28][CH:29]=1

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 159087TriacetoxyperiodinaneHCID 66839396(8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanolHCID 86585896Sodium bicarbonate water

生成物 1

HCID 86628503HCID 86628503、化合物収率 138.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Dess-Martin periodinane (304 mg) was added to a solution of (8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanol (165 mg) in methylene chloride (10 mL), and the reaction solution was stirred in a nitrogen atmosphere at room temperature for four hours. Ethyl acetate and saturated sodium bicarbonate water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 227 mg of the title compound. The property value of the compound is as follows.

後処理

  1. customthe organic layer was separated
  2. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ae5115b819604094a7146598cc72f466
出典データセット
uspto-grants-2011_05
特許番号
US07935815B2

反応ノート

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