tert-butyl 4-[1-(N'-benzyloxycarbonyl-hydrazinocarbonyl)-4-chlorobutan-1-yl]piperidine-1-carboxylate → Tert-butyl 4-[4-chloro-1-hydrazinocarbonyl-butan-1-yl]piperidine-1-carboxylate

HRID 546709ノート

反応式

HRID 546709 の反応式
C(OC([NH:11][NH:12][C:13]([CH:15]([CH:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]1)[CH2:16][CH2:17][CH2:18][Cl:19])=[O:14])=O)C1C=CC=CC=1>CO.[C].[Pd]>[Cl:19][CH2:18][CH2:17][CH2:16][CH:15]([CH:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]1)[C:13]([NH:12][NH2:11])=[O:14]

参加物

4

反応物 1

HCID 66839389tert-butyl 4-[1-(N'-benzyloxycarbonyl-hydrazinocarbonyl)-4-chlorobutan-1-yl]piperidine-1-carboxylate

生成物 1

HCID 66839238Tert-butyl 4-[4-chloro-1-hydrazinocarbonyl-butan-1-yl]piperidine-1-carboxylate収率 100.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

10% palladium-carbon (50% wet, 200 mg) was added to a solution of tert-butyl 4-[1-(N′-benzyloxycarbonyl-hydrazinocarbonyl)-4-chlorobutan-1-yl]piperidine-1-carboxylate (928 mg) in methanol (15 ml), and the reaction solution was hydrogenated at normal pressure at room temperature for 4.5 hours. The catalyst is removed by filtration and the filtrate is concentrated under reduced pressure to obtain 663 mg of the title compound. The property value of the compound is as follows.

後処理

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7042997d60f54e6b9e6befd6f63572e1
出典データセット
uspto-grants-2011_05
特許番号
US07935815B2

反応ノート

読み込み中…