4-Fluoro-3-methylphenylacetonitrile → 2-(4-Fluoro-3-methylphenyl)acetamide

HRID 546774ノート

反応式

HRID 546774 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][C:3]=1[CH3:11].C[Si](C)(C)[O:14][K].O.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH2:10])=[O:14])=[CH:4][C:3]=1[CH3:11]

参加物

5

反応物 3

HCID 201118384-Fluoro-3-methylphenylacetonitrileHCID 86585896Sodium bicarbonate waterHCID 178504318HCID 178504318、化合物

生成物 1

HCID 668394032-(4-Fluoro-3-methylphenyl)acetamide収率 70%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
110 °C

実験手順

4-Fluoro-3-methylphenylacetonitrile (1.1 g) was dissolved in toluene (35 ml), and trimethylsiloxypotassium (3.7 g) was added. After stirring at 110° C. for 2.5 hours, saturated sodium bicarbonate water was added, followed by separation with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to obtain 863 mg of the title compound. The property values of the compound are as follows.

後処理

  1. customfollowed by separation with ethyl acetate
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-11ced35569554d9dae2da493e6af642b
出典データセット
uspto-grants-2011_05
特許番号
US07935815B2

反応ノート

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