Ethanol hydrochloride → Ethyl 2-(4-fluoro-3-methylphenyl)acetate
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](N)=[O:10])=[CH:4][C:3]=1[CH3:12].Cl.[CH2:14]([OH:16])[CH3:15]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:16][CH2:14][CH3:15])=[O:10])=[CH:4][C:3]=1[CH3:12]参加物
3
反応条件
- 温度
- 85 °C
実験手順
2-(4-Fluoro-3-methylphenyl)acetamide (863 mg) was dissolved in saturated hydrochloric acid/ethanol (20 ml), and the reaction solution was stirred at 85° C. for 10 hours. The reaction solution was concentrated under reduced pressure and then diluted with ethyl acetate, followed by separation with water. The organic layer was washed with saturated aqueous sodium bicarbonate and brine and then dried over magnesium sulfate. 919 mg of the title compound was obtained by concentration under reduced pressure. The property values of the compound are as follows.
後処理
- concentrationThe reaction solution was concentrated under reduced pressure
- additiondiluted with ethyl acetate
- customfollowed by separation with water
- washThe organic layer was washed with saturated aqueous sodium bicarbonate and brine
- dry with materialdried over magnesium sulfate
出典と根拠
- ORDレコード
- ord-fe4bdb41fc8048189acf8eb1a3c10bc9
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07935815B2
反応ノート
読み込み中…