Hydrochloric Acid → E-2212
反応式
C(O[C@@H]([C@H](OC(=O)C1C=CC=CC=1)C(O)=O)C(O)=O)(=O)C1C=CC=CC=1.[CH3:27][O:28][C:29]1[N:34]=[C:33](/[CH:35]=[CH:36]/[C:37]2[N:55]=[C:40]3[C@H:41]([C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=4[C:51]([F:54])([F:53])[F:52])[CH2:42][CH2:43][CH2:44][N:39]3[N:38]=2)[CH:32]=[CH:31][C:30]=1[N:56]1[CH:60]=[C:59]([CH3:61])[N:58]=[CH:57]1.Cl>C(OCC)(=O)C>[CH3:27][O:28][C:29]1[N:34]=[C:33](/[CH:35]=[CH:36]/[C:37]2[N:55]=[C:40]3[C@H:41]([C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=4[C:51]([F:54])([F:53])[F:52])[CH2:42][CH2:43][CH2:44][N:39]3[N:38]=2)[CH:32]=[CH:31][C:30]=1[N:56]1[CH:60]=[C:59]([CH3:61])[N:58]=[CH:57]1参加物
4
実験手順
(8S)-2-{(E)-2-[6-Methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-[2-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine (2S,3S)-2,3-bis(benzoyloxy)succinate (1/1) (20 mg, 0.024 mmol) was added to the mixed solution of ethyl acetate (0.1 mL) and 5N HCl aq. (0.1 mL), and the organic layer was separated. Ethyl acetate (0.2 mL) and 5N sodium hydrate aq. (0.1 mL) were added to the aqueous layer, and the organic layer was separated. The organic layer was washed twice with water (0.1 mL), and dried under the reduced pressure to obtain the title compound (11.5 mg, 99.9% yield).