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1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amine → 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-piperidinoethyl)-benzimidazole hydrobromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-amine | HCID 566559 | — |
| 反応物 | 2-Bromo-1-(5-bromothiophen-2-yl)ethan-1-one | HCID 1988398 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-piperidinoethyl)-benzimidazole hydrobromide | HCID 19040891 | 82% |
反応手順
Add a solution of 5-bromo-2-bromoacetylthiophene (5.68 g, 20 mmol) in 30 ml of ether to a hot solution of 2-amino-1-(2-piperidinoethyl)-benzimidazole (4.88 g, 20 mmol) in 150 ml of acetone. Stir and maintain at room temperature for five hours. Suction-filter the precipitate, wash with acetone and then with ether to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05623073 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-3561e4cfe32445759c3dc24690ee59e2 |
| 出典メモ | uspto-grants-1997_04 |