Diethylamine → 9-Benzyl-2-diethylaminomethyl-3-ethoxycarbonylimidazo[1,2-a]benzimidazole
反応式
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[CH2:6]([N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]2[C:22]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:23]([CH2:25]Br)[N:24]=[C:14]12)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1C=CC=CC=1>[CH2:6]([N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]2[C:22]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:23]([CH2:25][N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])[N:24]=[C:14]12)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1参加物
4
実験手順
Add 1.04 ml (10 mmol) of diethylamine to a hot solution of 9-benzyl-2-bromomethyl-3-ethoxycarbonylimidazo[1,2-a]benzimidazole (2.01 g, 5 mmol), prepared as described for the alkylated analogues in Khim. Farm. ZH 88, 22 (7), 815-9, in 20 ml of benzene. Heat at reflux for one hour, cool. Remove the resulting precipitate, evaporate the benzene, and the residue is recrystallised by hexane to yield the title compound.