Acetic Acid → (3-chloro-5-fluoro-phenyl)-acetic Acid Methyl Ester

HRID 547028ノート

反応式

HRID 547028 の反応式
C[Si](C=[N+]=[N-])(C)C.[Cl:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]([OH:19])=[O:18])[CH:12]=[C:13]([F:15])[CH:14]=1.[C:20](O)(=O)C>CO.C1(C)C=CC=CC=1>[CH3:20][O:18][C:17](=[O:19])[CH2:16][C:11]1[CH:12]=[C:13]([F:15])[CH:14]=[C:9]([Cl:8])[CH:10]=1

参加物

6

反応物 3

HCID 176Acetic AcidHCID 167693TrimethylsilyldiazomethaneHCID 27348372-(3-Chloro-5-fluorophenyl)acetic acid

生成物 1

HCID 57443518(3-chloro-5-fluoro-phenyl)-acetic Acid Methyl Ester収率 99%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 1140Toluene溶媒

実験手順

Trimethylsilyldiazomethane (2 M solution in diethyl ether, 0.199 mL, 0.398 mmol) was added to a solution of (3-chloro-5-fluoro-phenyl)acetic acid (50 mg, 0.265 mmol) in methanol (0.5 mL) and toluene (2 mL), and the mixture was stirred at room temperature for 10 minutes. Acetic acid was added to the reaction mixture to terminate the reaction, and then the mixture was concentrated under reduced pressure to give the target compound as a colorless oil (53 mg, 99%).

後処理

  1. customto terminate
  2. customthe reaction
  3. concentrationthe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-39cb5eed227e4ff6b2ea509c8be8ddc8
出典データセット
uspto-grants-2011_05
特許番号
US07935688B2

反応ノート

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