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Methanol → Methyl 4-bromo-alpha-hydroxybenzeneacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Hexane | HCID 8058 | — |
| 反応物 | p-Bromomandelic acid | HCID 97930 | — |
| 反応物 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Methyl 4-bromo-alpha-hydroxybenzeneacetate | HCID 14571696 | 93.2% |
反応手順
A solution of trimethylsilyldiazomethane in hexane (2 M, 1.4 mL, 2.8 mmol) was added to a solution of 4-bromo-phenyl-hydroxy-acetic acid (506 mg, 2.19 mmol) in benzene (2.1 mL)-methanol (1.0 mL) under cooling with ice, and the mixture was stirred at room temperature for five minutes. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate=3/1) to give the title compound (500 mg, 93%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07935688B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-b20975e893d9451080f5f154d764a445 |
| 出典メモ | uspto-grants-2011_05 |