Acetic Acid → Methyl 2-(5-bromo-2-methoxyphenyl)acetate

HRID 547145

反応式

HRID 547145 の反応式
C[Si](C=[N+]=[N-])(C)C.[Br:8][C:9]1[CH:10]=[CH:11][C:12]([O:19][CH3:20])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=1.[C:21](O)(=O)C>CO.C1(C)C=CC=CC=1>[CH3:21][O:17][C:16](=[O:18])[CH2:15][C:13]1[CH:14]=[C:9]([Br:8])[CH:10]=[CH:11][C:12]=1[O:19][CH3:20]

参加物

6

反応物 3

HCID 176Acetic AcidHCID 167693TrimethylsilyldiazomethaneHCID 5553065-Bromo-2-methoxyphenylacetic acid

生成物 1

HCID 21999895Methyl 2-(5-bromo-2-methoxyphenyl)acetate収率 98%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 1140Toluene溶媒

実験手順

Trimethylsilyldiazomethane (2 M solution in diethyl ether, 0.306 mL, 0.612 mmol) was added to a solution of (5-bromo-2-methoxy-phenyl)-acetic acid (100 mg, 0408 mmol) in methanol (1 mL) and toluene (4 mL), and the mixture was stirred at room temperature for 30 minutes. Acetic acid was added to the reaction mixture to terminate the reaction, and then the mixture was concentrated under reduced pressure to give the target compound as a colorless oil (103.7 mg, 98%).

後処理

  1. customto terminate
  2. customthe reaction
  3. concentrationthe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-da01d3947f874f5b9db67375d3a68dac
出典データセット
uspto-grants-2011_05
特許番号
US07935688B2

関連ノート

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