Hydrazine → HCID 178525216、化合物

HRID 547150

反応式

HRID 547150 の反応式
[NH2:1][NH2:2].[O:3]=[C:4]1[C:8]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][C:6](=O)[O:5]1>C(O)(=O)C>[OH:5][C:6]1[CH:7]=[C:8]([CH2:9][C:10]([OH:12])=[O:11])[C:4](=[O:3])[NH:1][N:2]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 65163Aconitic anhydride

生成物 1

HCID 178525216HCID 178525216、化合物収率 80.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

A solution of hydrazine (103 mg, 3.21 mmol) in acetic acid (16 mL) was added to (2,5-dioxo-2,5-dihydro-furan-3-yl)acetic acid (500 mg, 3.04 mmol) under cooling with ice, and the mixture was heated with stirring at an external temperature of 76 to 84° C. for one hour. The reaction mixture was concentrated under reduced pressure. The resulting solid was sequentially washed with water, ethanol and ether to give the title compound (414 mg, 80%).

後処理

  1. temperatureunder cooling with ice
  2. temperaturethe mixture was heated
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. washThe resulting solid was sequentially washed with water, ethanol and ether

出典と根拠

ORDレコード
ord-cff7547648714211adb0e715f20ea4c8
出典データセット
uspto-grants-2011_05
特許番号
US07935688B2

関連ノート

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