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Hydrochloric Acid → HCID 22478250、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| 反応物 | 4,7-Dichloro-6-nitroquinazoline | HCID 10490455 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | HCID 22478250 | HCID 22478250 | 90% |
反応手順
A mixture of 4,7-dichloro-6-nitroquinazoline (24.4 g, 0.1 mol), 4-chloro-2-fluoroaniline and ethereal hydrogen chloride (100 ml of a 1M solution) in 2-propanol (600 ml) was heated at reflux for 1.5 hours. The mixture was allowed to cool and diluted with acetone. The solid product was collected by filtration, washed with acetone and dried to give 7-chloro-4-(4-chloro-2-fluoroanilino)-6nitroquinazoline hydrochloride (35.0 g, 90%) as a yellow powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE042353E1 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-9b64e283a6044048b2a081954f550360 |
| 出典メモ | uspto-grants-2011_05 |