Gamma-Butyrolactone → 1-(3-Hydroxypropyl)pyrrolidin-2-one
反応式
[C:1]1(=O)[O:5][CH2:4][CH2:3][CH2:2]1.[NH2:7][CH2:8][CH2:9][CH2:10][OH:11]>>[OH:11][CH2:10][CH2:9][CH2:8][N:7]1[CH2:1][CH2:2][CH2:3][C:4]1=[O:5]参加物
3
実験手順
A solution of γ-butyrolactone (8.6g, 0.1 mol) and 3-amino-1-propanol (9 g, 0.12 mol) was heated at reflux for 18 hours. The crude product mixture was distilled under reduced pressure to give 1-(3-hydroxypropyl)-2-pyrrolidinone (2.5 g. 17%).
後処理
- temperatureat reflux for 18 hours
- distillationThe crude product mixture was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-1ef7b81bd68a432baf3fd4f9e4de4b04
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- USRE042353E1
反応ノート
読み込み中…