Propionic Acid → 3,4-Dipropionyloxy-1-butene

HRID 54726

反応式

HRID 54726 の反応式
[C:1]([O:5][C:6](=O)[CH2:7][CH3:8])(=[O:4])[CH2:2][CH3:3].[CH2:10](N(CC)CC)C.[C:17]([OH:21])(=[O:20])[CH2:18][CH3:19].O1CC1C=C>COCCOCCOC>[C:17]([O:21][CH:7]([CH2:6][O:5][C:1](=[O:4])[CH2:2][CH3:3])[CH:8]=[CH2:10])(=[O:20])[CH2:18][CH3:19]

参加物

6

反応物 4

HCID 1032Propionic AcidHCID 8471TriethylamineHCID 13586VinyloxiraneHCID 31263Propionic anhydride

生成物 1

HCID 212251023,4-Dipropionyloxy-1-butene収率 90%

試薬・触媒・溶媒 1

HCID 8150Diglyme溶媒

反応条件

温度
125 °C

実験手順

A 100-mL autoclave was charged with 57.2 g (0.44 mol) propionic anhydride, 1.62 g (0.016 mol) of triethylamine, 1.2 g (0.016 mol) of propionic acid and 3.44 g of diglyme. The autoclave was purged with helium twice, then the vessel was pressurized to 6.2 bars (75 psig) with helium followed by agitation. The reaction mixture was heated to 125° C., then 31.35 mL (0.40 mol) of 3,4-epoxy-1-butene was introduced to the reactor via syringe pump over 10 seconds. A first sample was taken at 1 min, then sequential samples were obtained every 15 min during the course of 2 hrs for analysis by GC. GC analysis of the crude mixture after 2 hrs revealed a 90% yield of 3,4-dipropionyloxy-1-butene with a 91% selectivity and 6% 3,4-epoxy-1-butene. The reaction was observed to be first order in 3,4-epoxy-1-butene with a first order rate constant of 0.017 min-1 (Table A). This example shows the use of another carboxylic anhydride with its conjugate carboxylic acid.

後処理

  1. customThe autoclave was purged with helium twice
  2. customsequential samples were obtained every 15 min during the course of 2 hrs for analysis by GC

出典と根拠

ORDレコード
ord-d4628cb5db4245138f2f75b0cd4d53b8
出典データセット
uspto-grants-1997_04
特許番号
US05623086

関連ノート

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