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tert-Butyl (1S,4S)-5-(4-hydroxybenzyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate → 4-Piperidin-1-ylmethyl-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl (1S,4S)-5-(4-hydroxybenzyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | HCID 57514842 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Piperidin-1-ylmethyl-phenol | HCID 11636972 | — |
反応手順
The title compound was prepared using methods analogous to those described for Intermediate 35, substituting DCE for CH2Cl2. 1H NMR (500 MHz, CDCl3): 7.14-7.03 (m, 2H), 6.75 (br s, 1H), 6.62-6.53 (m, 2H), 3.41 (s, 2H), 2.49 (s, 4H), 1.66-1.59 (m, 4H), 1.50-1.42 (m, 2H). MS (ESI): mass calcd. for C12H17NO, 191.13; m/z found, 192.20 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07939527B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-2d08a74c40b9466980c3fc8ec6b5ec6c |
| 出典メモ | uspto-grants-2011_05 |