Hydrochloric Acid → 5-[2-(Amino)ethylthio]-3-nitroimidazo[1,2-a]pyridine,dihydrochloride
反応式
C(OC([NH:8][CH2:9][CH2:10][S:11][C:12]1[N:17]2[C:18]([N+:21]([O-:23])=[O:22])=[CH:19][N:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[ClH:24].[NH2:8][CH2:9][CH2:10][S:11][C:12]1[N:17]2[C:18]([N+:21]([O-:23])=[O:22])=[CH:19][N:20]=[C:16]2[CH:15]=[CH:14][CH:13]=1参加物
4
実験手順
To a suspension of 5-[2-(tert-butoxycarbonylamino)ethylthio]-3-nitroimidazo[1,2-a]pyridine (364 mg, 1.08 mmoles) in methanol (3 ml) was added conc. hydrochloric acid (2 ml) and the mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off to obtain 340 mg of the desired product (quantitative, brown solid).
後処理
- distillationThen, the solvent was distilled off
出典と根拠
- ORDレコード
- ord-9476683574db42fea1b85ced5bf91a51
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05244908
反応ノート
読み込み中…