Benzylamine → N-benzyl-2-(5-bromopyridin-2-yl)acetamide
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[C:8]2[C:13](=[O:14])OC(C)(C)OC2=O)[NH:6][CH:7]=1.[CH2:18]([NH2:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C1(C)C=CC=CC=1>[CH2:18]([NH:25][C:13](=[O:14])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1参加物
4
実験手順
A flask was charged with 5-(5-bromopyridin-2(1H)-ylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (1.039 g, 3.46 mmol), benzylamine (0.50 mL, 4.58 mmol), and toluene (20 mL). The reaction was brought to reflux under nitrogen for 18 hours, then cooled and placed in a freezer until cold. The product Was collected by filtration and washed with hexanes to yield a mass of bright white crystals (1.018 g, 96%).
後処理
- temperatureto reflux under nitrogen for 18 hours
- temperaturecooled
- filtrationThe product Was collected by filtration
- washwashed with hexanes
出典と根拠
- ORDレコード
- ord-5b8f85c070cd4d9cb86eca0bce1e5d38
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07939529B2
反応ノート
読み込み中…