Water → 2-(3,5-Dichlorophenyl)-2-methylpropanoic acid

HRID 547751ノート

反応式

HRID 547751 の反応式
C[O:2][C:3](=[O:15])[C:4]([C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Cl:14])[CH:8]=1)([CH3:6])[CH3:5].O>C(O)C>[Cl:13][C:11]1[CH:12]=[C:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:15])=[O:2])[CH:8]=[C:9]([Cl:14])[CH:10]=1

参加物

4

反応物 2

HCID 962WaterHCID 671939532-(3,5-Dichloro-phenyl)-2-methyl-propionic acid methyl ester

生成物 1

HCID 589907192-(3,5-Dichlorophenyl)-2-methylpropanoic acid収率 98.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 9.0 g (36 mmol) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid methyl ester in 40 ml ethanol 40 ml 2 N sodium hydroxide solution was added. After stirring for 4 hrs at RT 150 ml water was added and the solution washed twice with 200 ml Et2O. The aqueous phase was acidified with 25% hydrochloric acid solution and three times extracted with 150 ml CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and evaporated to yield 8.3 g (97%) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid as a off-white solid.

後処理

  1. additionwas added
  2. washthe solution washed twice with 200 ml Et2O
  3. extractionextracted with 150 ml CH2Cl2
  4. dry with materialThe combined organic layers were dried (Na2SO4)
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-ae7cf2c6725c40ed91ec22883b398bcc
出典データセット
uspto-grants-2011_05
特許番号
US07939533B2

反応ノート

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