関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | 2-Bromo-5-fluorobenzaldehyde | HCID 2773321 | — |
| 触媒 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(2-Bromo-5-fluorophenyl)-1,3-dioxolane | HCID 67196455 | 95% |
反応手順
To a solution of 2.0 g (9.9 mmol) 2-bromo-5-fluorobenzaldehyde in 20 ml toluene were added 0.722 ml (13.0 mmol) ethane-1,2-diol and 5 mg (0.03 mmol) toluene-4-sulfonic acid monohydrate. The reaction mixture was heated in a rotary evaporator at 60° C. and 200 mbar during 4 h. After evaporation of the solvent and flash chromatography 2.32 g (95%) of the title compound were obtained as a colorless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07939533B2 |
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| 出典データセット | uspto-grants-2011_05 |
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| ORD ID | ord-e4fd57c228cc4e2f94cf88b7f8efc373 |
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| 出典メモ | uspto-grants-2011_05 |
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