化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Piperidin-4-yl-pyrimidin-5-yl-amine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-(Pyrimidin-5-ylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 67198211 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Piperidin-4-yl-pyrimidin-5-yl-amine dihydrochloride | HCID 67196781 | — |
反応手順
A solution of 4-(pyrimidin-5-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.30 g, 4.67 mmol) in 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 179.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07939661B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-4d30a8df9b104fffb55eb874fa7d86c4 |
| 出典メモ | uspto-grants-2011_05 |