2-Bromopropane → Methyl 2-(4-bromophenyl)-3-methylbutanoate

HRID 547981ノート

反応式

HRID 547981 の反応式
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1.[CH3:13][C:14](C)([O-])[CH3:15].[K+].C(Br)(C)C>CN(C=O)C>[CH3:1][O:2][C:3](=[O:12])[CH:4]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)[CH:14]([CH3:15])[CH3:13]

参加物

5

反応物 3

HCID 63582-BromopropaneHCID 316783Methyl 2-(4-bromophenyl)acetateHCID 23665647Potassium tert-butoxide

生成物 1

HCID 46855859Methyl 2-(4-bromophenyl)-3-methylbutanoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The (4-bromophenyl)acetic acid methyl ester in the Step 1 and potassium t-butoxide (4.8 g, 1 eq) were dissolved in 200 ml DMF at 0° C. Isopropyl bromide (4 ml. 1 eq) was added into the mixture and stirred at room temperature for 3 hours. When the reaction was completed, the mixture was extracted 3 times with ethyl acetate and water, and washed with saline solution. After the organic layer was dried with anhydrous and the solvent was removed at low pressures, the target compound 2-(4-bromophenyl)3-methylbutyric acid methyl ester was obtained by separation and purification of the mixture using a column chromatography (ethyl acetate:n-hexane=1:10) (6.60 g, 57%).

後処理

  1. extractionthe mixture was extracted 3 times with ethyl acetate and water
  2. washwashed with saline solution
  3. customAfter the organic layer was dried with anhydrous and the solvent
  4. customwas removed at low pressures

出典と根拠

ORDレコード
ord-d6dda329598045ae8ef0c73881bba2ed
出典データセット
uspto-grants-2011_05
特許番号
US07939672B2

反応ノート

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