4-(Bromomethyl)-2-fluoro-1-methoxybenzene → 4-(N-(3-fluoro-4-methoxybenzyl)-N-(4-methoxybenzyl)sulfamoyl)-benzoic acid

HRID 548075

反応式

HRID 548075 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([F:11])[CH:4]=1.[CH3:12][O:13][C:14]1[CH:34]=[CH:33][C:17]([CH2:18][NH:19][S:20]([C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29]C)=[O:28])=[CH:25][CH:24]=2)(=[O:22])=[O:21])=[CH:16][CH:15]=1>>[F:11][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][C:6]=1[O:9][CH3:10])[CH2:2][N:19]([CH2:18][C:17]1[CH:33]=[CH:34][C:14]([O:13][CH3:12])=[CH:15][CH:16]=1)[S:20]([C:23]1[CH:24]=[CH:25][C:26]([C:27]([OH:29])=[O:28])=[CH:31][CH:32]=1)(=[O:22])=[O:21]

参加物

3

反応物 2

HCID 27745534-(Bromomethyl)-2-fluoro-1-methoxybenzeneHCID 26527056Methyl 4-(N-(4-methoxybenzyl)sulfamoyl)benzoate

生成物 1

HCID 579449604-(N-(3-fluoro-4-methoxybenzyl)-N-(4-methoxybenzyl)sulfamoyl)-benzoic acid

実験手順

Prepared as in example 5-10 from 4-(bromomethyl)-2-fluoro-1-methoxybenzene and methyl 4-(N-(4-methoxybenzyl)sulfamoyl)benzoate (example 5-10b). MS (M−H, 458.10); 1H NMR (400 MHz, CD3OD): δ, ppm: 3.73 (s, 3H), 3.80 (s, 3H), 4.24 (s, 2H), 4.28 (s, 2H), 6.75 (m, 4H), 6.88 (m, 1H), 6.97 (d, 2H, J=8.6 Hz), 7.88 (d, 2H, J=8.3 Hz), 8.14 (d, 2H, J=8.3 Hz).

出典と根拠

ORDレコード
ord-9ac1e066d7e446d6b46fc436b6c43271
出典データセット
uspto-grants-2011_05
特許番号
US07939671B2

関連ノート

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