Water → 1,4-Dimethylquinoxaline-2,3-dione

関与物質

役割	名称	HCID	仕込み量
反応物	Water	HCID 962	—
反応物	Dimethylformamide	HCID 6228	—
反応物	Methyl iodide	HCID 6328	—
反応物	Sodium hydride	HCID 24758	—
反応物	2,3-Dihydroxyquinoxaline	HCID 27491	—
生成物	1,4-Dimethylquinoxaline-2,3-dione	HCID 351421	95%

反応手順

To a solution of NaH (2.5 g) in DMF (200 mL) was added quinoxaline-2,3(1H,4H)-dione (5 g) in portions, followed by the slow addition of methyl iodide (3.8 mL). The reaction mixture was stirred at ambient temperature for 4 hours, then water was added (200 mL) The resulting precipitate was collected by filtration and washed with water to afford 1,4-dimethylquinoxaline-2,3(1H,4H)-dione as a white solid in 95% yield. 1H NMR (400 MHz, DMSO-d6): δ, ppm: 3.50 (s, 6H), 7.25 (m, 2H), 7.38 (m, 4H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07939671B2
出典データセット	uspto-grants-2011_05
ORD ID	ord-de036f45e6f94576b5b625da91cf23fc
出典メモ	uspto-grants-2011_05