化工社化工社 化学情報印刷レポート · 研究参考用
Ethylene Glycol → 1,4-Dioxa-8-thiaspiro(4.5)decane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Tetrahydrothiopyran-4-one | HCID 66173 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1,4-Dioxa-8-thiaspiro(4.5)decane | HCID 12335978 | — |
反応手順
A mixture of 5.0 g of tetrahydrothiopyran-4-one, 2.5 ml of ethylene glycol, 0.230 g of p-toluenesulfonic acid and 125 ml of benzene is stirred at reflux temperature for 2.5 hours. The water formed is removed using a Dean-Stark trap. The reaction is treated with saturated sodium bicarbonate, water, saturated sodium chloride, dried and concentrated in vacuo to give 6.52 g of the desired product as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05623081 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-3e940006c8d94ab8a3f705c659dcaa0b |
| 出典メモ | uspto-grants-1997_04 |