Ethylene Glycol → 1,4-Dioxa-8-thiaspiro(4.5)decane

HRID 54831

反応式

HRID 54831 の反応式
[S:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[CH2:8](O)[CH2:9][OH:10].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>O>[O:10]1[C:4]2([CH2:5][CH2:6][S:1][CH2:2][CH2:3]2)[O:7][CH2:8][CH2:9]1

参加物

6

反応物 4

HCID 174Ethylene GlycolHCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 66173Tetrahydrothiopyran-4-one

生成物 1

HCID 123359781,4-Dioxa-8-thiaspiro(4.5)decane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5.0 g of tetrahydrothiopyran-4-one, 2.5 ml of ethylene glycol, 0.230 g of p-toluenesulfonic acid and 125 ml of benzene is stirred at reflux temperature for 2.5 hours. The water formed is removed using a Dean-Stark trap. The reaction is treated with saturated sodium bicarbonate, water, saturated sodium chloride, dried and concentrated in vacuo to give 6.52 g of the desired product as an oil.

後処理

  1. temperatureat reflux temperature for 2.5 hours
  2. customis removed
  3. additionThe reaction is treated with saturated sodium bicarbonate, water, saturated sodium chloride
  4. customdried
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3e940006c8d94ab8a3f705c659dcaa0b
出典データセット
uspto-grants-1997_04
特許番号
US05623081

関連ノート

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