Hydrochloric Acid → 4-Chloro-3-mercapto-2-methylbenzoic acid
反応式
[OH-].[K+].[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10]C)=[O:9])=[C:6]([CH3:14])[C:5]=1[S:15]C(N(C)C)=O.O.Cl>CO>[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([OH:10])=[O:9])=[C:6]([CH3:14])[C:5]=1[SH:15]参加物
6
実験手順
6.61 g (purity 85% by weight, 100.1 mmol) of KOH were added to 4.80 g (16.7 mmol) of methyl 4-chloro-3-(dimethylaminocarbonylthio)-2-methylbenzoate in 150 ml of methanol, and the mixture was stirred under reflux for two days. The reaction mixture was freed from solvent, water was added to the residue, which was then acidified with 1M HCl, and the solid was collected by filtration. This gave 3.2 g of pure product.
後処理
- temperatureunder reflux for two days
- additionwas added to the residue, which
- filtrationthe solid was collected by filtration
出典と根拠
- ORDレコード
- ord-aa83821db1ab4b92898a4d5ba1be772c
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07943551B2
反応ノート
読み込み中…