3,6-Dichloro-4-methylpyridazine → 3-Chloro-4-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine
反応式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][OH:14].[Cl:15][C:16]1[N:17]=[N:18][C:19](Cl)=[CH:20][C:21]=1[CH3:22]>>[Cl:15][C:16]1[N:17]=[N:18][C:19]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[CH:20][C:21]=1[CH3:22]参加物
3
実験手順
As described for example 4, (5-methyl-3-phenyl-4-isoxazolyl)methanol (5.00 g, 26.4 mmol) was converted using 3,6-dichloro-4-methylpyridazine instead of 3-chloro-6-methylpyridazine to the title compound (4.59 g, 55%) which was obtained as a yellow oil. MS: m/e=316.1 [M]+.
出典と根拠
- ORDレコード
- ord-7f03b5419ba54c528c4a4d3b922c9004
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07943619B2
反応ノート
読み込み中…