3,6-Dichloro-4-methylpyridazine → 3-Chloro-4-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine

HRID 548841

反応式

HRID 548841 の反応式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][OH:14].[Cl:15][C:16]1[N:17]=[N:18][C:19](Cl)=[CH:20][C:21]=1[CH3:22]>>[Cl:15][C:16]1[N:17]=[N:18][C:19]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[N:5][O:6][C:2]=2[CH3:1])=[CH:20][C:21]=1[CH3:22]

参加物

3

反応物 2

HCID 879233,6-Dichloro-4-methylpyridazineHCID 2776149(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol

生成物 1

HCID 426296503-Chloro-4-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine収率 55%

実験手順

As described for example 4, (5-methyl-3-phenyl-4-isoxazolyl)methanol (5.00 g, 26.4 mmol) was converted using 3,6-dichloro-4-methylpyridazine instead of 3-chloro-6-methylpyridazine to the title compound (4.59 g, 55%) which was obtained as a yellow oil. MS: m/e=316.1 [M]+.

出典と根拠

ORDレコード
ord-7f03b5419ba54c528c4a4d3b922c9004
出典データセット
uspto-grants-2011_05
特許番号
US07943619B2

関連ノート

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