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Dichloromethane → (RS)-S-Methyl-S-(4-nitrophenyl)-N-[(4-chloro-3-pyridyl)sulphonyl]sulphimide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | 4-Nitrophenyl methyl sulfide | HCID 96109 | — |
| 反応物 | Magnesium monoxide | HCID 6850729 | — |
| 反応物 | 5-Chloropyridine-3-sulfonamide | HCID 54594706 | — |
| 反応物 | Acetic acid;iodosylbenzene | HCID 73357407 | — |
| 触媒 | Dirhodium tetraacetate | HCID 152122 | — |
| 生成物 | (RS)-S-Methyl-S-(4-nitrophenyl)-N-[(4-chloro-3-pyridyl)sulphonyl]sulphimide | HCID 59683173 | 46% |
反応手順
879 mg (2.73 mmol) of iodosobenzene diacetate are added to a suspension of 300 mg (1.77 mmol) of 1-methylsulphanyl-4-nitrobenzene, 683 mg (3.55 mmol) of 5-chloro-3-pyridinesulphonamide, 285 mg (7.10 mmol) of magnesium oxide and 78 mg (0.18 mmol) of rhodium(II) acetate dimer in 12 ml of dichloromethane at room temperature. The mixture is stirred for 24 h and then concentrated. The resulting residue is purified by chromatography (dichloromethane/ethanol 95:5). 294 mg (0.82 mmol; yield: 46%) of the product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07943629B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-5c9938856bf541adb341dac74ee22871 |
| 出典メモ | uspto-grants-2011_05 |