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Cyanoacetic acid → (7-Methoxy-1-benzofuran-3-yl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyanoacetic acid | HCID 9740 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | 7-Methoxybenzofuran-3(2H)-one | HCID 2818112 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | (7-Methoxy-1-benzofuran-3-yl)acetonitrile | HCID 15618729 | 30% |
反応手順
The solution of 7-methoxy-1-benzofuran-3(2H)-one (reference) (7.5 g, 0.046 mol), cyanoacetic acid (19.55 g, 0.23 mol) and ammonium acetate (7.08 g, 0.092 mol) in xylene was refluxed for 16-18 h. using dean stark apparatus. Xylene was removed under diminished pressure. Brown black residue was taken in ethyl acetate, washed with water and concentrated. On purification on silica gel it yielded (7-methoxy-1-benzofuran-3-yl)acetonitrile (30%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07943634B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-ac3f40c2faa7422a8e9aaa0d2bc845a9 |
| 出典メモ | uspto-grants-2011_05 |