Phenylglycine nitrile → 1H-Indazole-3-carbonitrile

HRID 549067

反応式

HRID 549067 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][C:5]#[N:6].[N:11]([O-])=O.[Na+]>Cl>[C:5]([C:4]1[C:3]2[C:2](=[CH:10][CH:9]=[CH:8][CH:7]=2)[NH:1][N:11]=1)#[N:6]

参加物

4

反応物 2

HCID 76307Phenylglycine nitrileHCID 23668193Sodium Nitrite

生成物 1

HCID 4375561H-Indazole-3-carbonitrile

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A solution of o-aminobenzyl cyanide (0.5 g) in aqueous hydrochloric acid 1N (9.6 mL), was treated with a solution of aqueous sodium nitrite 1N (3.85 mL). After stirring at room temperature for 15 minutes, the reaction mixture was filtered. The solid was recrystallised from ethanol to give the title compound (0.4 g) as a yellow solid, m.p. 138-140° C. 1H NMR [(CD3)2SO]: δ 7.89 (d, 1H, J=7.7 Hz); 7.76 (d, 1H, J=7.9 Hz); 7.48 (t, 1H); 7.41 (t, 1H).

後処理

  1. filtrationthe reaction mixture was filtered
  2. customThe solid was recrystallised from ethanol

出典と根拠

ORDレコード
ord-99b2645688ee40448ec16adfb554ec7a
出典データセット
uspto-grants-2011_05
特許番号
US07943616B2

関連ノート

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